The benefits seen in pre-clinical studies show that enhancing maximum blood flow can be applied to many health benefits.

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NITROSIGINE® is a Patented Complex of Inositol Stabilized Arginine Silicate, Accepted by the FDA as a New Dietary Ingredient

Research has shown dramatic protective effects of the novel amino acid compound arginine silicate in pre-clinical studies. The benefits seen in enhancing maximum blood flow can be applied to many health benefits. Nitrosigine® provides all the benefits of arginine, silicon, and potassium with additional benefits from the unique combination.

Arginine has been studied extensively since 1998 as a natural metabolic donor of nitric oxide. Higher nitric oxide related maximum blood flow and vessel relaxation achieved with Nitrosigine® offer many health benefits. There is also accumulated evidence over the past 35 years suggesting an important role for silicon in connective tissue.


Nitrosigine® Science Highlights:
The new clinical study demonstrated significant increases in plasma arginine levels (P<0.01) and serum silicon levels (P<0.01) after a single dose of Nitrosigine®.*3 In addition, a significant increase in nitric oxide levels (measured as salivary nitrites) was seen after 14 days of product consumption (P<0.05).*3

The clinical study that verified daily Nitrosigine® supplementation increased nitric oxide (NO) levels with a significant change in NO levels at 14 days.*3 The increase in NO levels can promote relaxation of smooth muscle in blood vessels, which increases blood flow and improves cardiovascular and muscular health.

Consumer benefits directly linked to the clinical study findings include*3:

  • Nitrosigine® significantlyboosts nitric oxide (NO) levels, a key factor
    in increasing blood flow
  • Nitrosigine® is a safe, bioavailable source of arginine and silicon
  • Nitrosigine® takes effect in as quickly as 30 minutes
  • Nitrosigine® keeps delivering benefits up to 3 hours after a single
  • Nitrosigine® significantly increases silicon levels for up to 1.5 hours
  • With continued use of Nitrosigine®, nitric oxide levels build over time,
    leading to even better blood flow and vessel flexibility.

Research has shown dramatic protective effects of the novel amino acid complex arginine silicate in pre-clinical animal studies.

  • Nitrosigine® almost doubles maximum blood flow compared to
    Arginine HCl and is 4x greater than Control *1
  • Nitrosigine® blood vessel relaxation is almost 5x greater than
    Arginine HCl *1
  • Nitrosigine® supplementation significantly increased silicon
    blood levels compared to normal dietary intake *2
  • Higher nitric oxide related maximum blood flow & vessel relaxation
    achieved with Nitrosigine® offer many health benefits

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*1. Proctor SD, Kelly SE, Russell JC. A novel complex of arginine-silicate improves micro- and macrovascular function and inhibits glomerular sclerosis in insulin-resistant JCR:LA-cp rats. Diabetologia. 2005 Sep;48(9):1925-32.
*2. Proctor SD, Kelly SE, Vine DF, Russell JC. Metabolic effects of a novel silicate inositol complex of the nitric oxide precursor arginine in the obese insulin-resistant JCR:LA-cp rat. Metabolism. 2007 Oct;56(10):1318-25.
*3. Presented at The Experimental Biology (EB) 2014 meeting held at the San Diego Convention Center, April 30, 2014 and in the Federation of American Societies for Experimental Biology journal (FASEB).

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