Nitrosigine® is a patented complex of Bonded Arginine Silicate clinically studied and proven to boost nitric oxide production for improved blood flow, supporting oxygen and nutrient delivery, healthy working muscles, and better cognitive performance.

A powerful, safe, and non-stimulant ingredient, Nitrosigine is supported by more than 8 clinical studies and demonstrated to enhance nitric oxide levels in the body. Nitrosigine can be formulated into a range of active wellness and pre-workout products including tablets, capsules, powders, beverages, and bars.

The unique complex of arginine and silicon in Nitrosigine unlocks powerful synergistic effects that offer enhanced benefits. Arginine contributes to boosting nitric oxide (NO) levels, which has been shown to be a key factor in generating greater blood flow and vasodilation in working muscles. Meanwhile, silicon contributes to blood flow by strengthening and improving the flexibility of arterial walls. Together, these ingredients offer powerful efficacious results compared to each ingredient alone. Nitrosigine increases blood levels of arginine for up to six hours and elevates blood levels of silicon with a single dose.

Size Does Matter: In March of 2020, researchers at The University of Arkansas published an independent study that showed that a single dose of Nitrosigine increases blood flow and vasodilation. In fact, it only took 1.5g of Nitrosigine vs. 8g of Citrulline Malate to achieve the same result.

WHAT IS NITROSIGINE?
HOW DOES NITROSIGINE WORK?
WHAT IS NITROSIGINE?

Nitrosigine® is a patented complex of Bonded Arginine Silicate clinically studied and proven to boost nitric oxide production for improved blood flow, supporting oxygen and nutrient delivery, healthy working muscles, and better cognitive performance.

 

A powerful, safe, and non-stimulant ingredient, Nitrosigine is supported by more than 8 clinical studies and demonstrated to enhance nitric oxide levels in the body. Nitrosigine can be formulated into a range of active wellness and pre-workout products including tablets, capsules, powders, beverages, and bars.

HOW DOES NITROSIGINE WORK?

The unique complex of arginine and silicon in Nitrosigine unlocks powerful synergistic effects that offer enhanced benefits. Arginine contributes to boosting nitric oxide (NO) levels, which has been shown to be a key factor in generating greater blood flow and vasodilation in working muscles. Meanwhile, silicon contributes to blood flow by strengthening and improving the flexibility of arterial walls. Together, these ingredients offer powerful efficacious results compared to each ingredient alone. Nitrosigine increases blood levels of arginine for up to six hours and elevates blood levels of silicon with a single dose.

 

Size Does Matter: In March of 2020, researchers at The University of Arkansas published an independent study that showed that a single dose of Nitrosigine increases blood flow and vasodilation. In fact, it only took 1.5g of Nitrosigine vs. 8g of Citrulline Malate to achieve the same result.

Nitrosigine, By The Numbers

20

20 patents and pending applications worldwide

30+

Supported by more than 30 studies, including 8 human clinical studies

100+

Over 100 brands use Nitrosigine

Real World Results

Nutrition21 has conducted 100 studies and counting to support the safety and effectiveness of our ingredients. This research has helped us carve out unique product claims for our customers in the dietary supplement, food and beverage, and sports nutrition industries.

  • Nitrosigine boosts nitric oxide levels in the body
  • Nitrosigine increases vasodilation to promote healthy blood flow

  • Nitrosigine increases blood arginine levels quickly within 30 minutes and lasts in circulation for up to 6 hours
  • Nitrosigine provides a bioavailable forms of arginine and silicon

  • Nitrosigine increases blood flow into working muscles, boosting muscle pump

  • Nitrosigine significantly increases cognitive function, mental acuity, and focus
  • Nitrosigine helps keep your mind sharp even during intense exercise

  • Nitrosigine helps keep you energized
  • A caffeine-free and non-stim way to support energy

Science That Powers Nitrosigine

Common Applications

Nitrosigine is GRAS, non-stimulant ingredient that is easily formulated into a variety of dietary supplement and functional food/beverage applications including ready to drink (RTD) beverages, pre-workout powders and dry mixes, bars, gels, capsules, and more! Nitrosigine has FDA new dietary ingredient (NDI) notification status.

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Where To Find Nitrosigine

Nutrition21 provides ingredient solutions to some of the most successful brands in the consumer marketplace today. If you are a consumer looking for the benefits of Nutrition21’s exclusive ingredients, check out our ingredients in action, on our customers’ labels:

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Get in touch

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non GMOVeganGluten Freeno major allergens

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Nitrosigine®, Velositol®, nooLVL®, Lustriva®, Chromax®, Zinmax®, and their associated logos are registered trademarks of Nutrition21, LLC.  All third party trademarks are the property of their respective owners. Nutrition21, LLC's products are protected by a number of patents including, but not limited to: US Patent Nos. 6,809,115; 6,803,456; 7,576,132; 8,062,677; 8,933,022; 9,028,879; 9,119,835; 9,597,404; 9,675,702; 10,183,049; and 10,245,325.

*These statements have not been evaluated by the Food and Drug Administration. These products are not intended to diagnose, treat, cure, or prevent any disease.

1 Results compared to baseline
2 Perceived energy measured by the validated Profile of Mood States (POMS) questionnaire
3 With globally sourced ingredients