Nitrosigine® is a patented complex of Bonded Arginine Silicate that is scientifically engineered to deliver benefits essential to peak sports performance. Nitrosigine is a powerful and safe non-stimulant ingredient that has been clinically studied for safety and efficacy in 30 studies. The use of Nitrosigine has been shown to promote nitric oxide (NO) production for improved blood flow1, focus, and energy.2

The unique complex of arginine and silicon in Nitrosigine unlocks powerful synergistic effects that offer enhanced benefits. Arginine contributes to boosting nitric oxide (NO) levels, which has been shown to be a key factor in generating greater blood flow and vasodilation in working muscles. Meanwhile, silicon contributes to blood flow by strengthening and improving the flexibility of arterial walls. Together, these ingredients offer powerful efficacious results compared to each ingredient alone. Nitrosigine increases blood levels of arginine for up to six hours and elevates blood levels of silicon with a single dose.

Size Does Matter: In March of 2020, researchers at The University of Arkansas published an independent study that showed that a single dose of Nitrosigine increases blood flow and vasodilation. In fact, it only took 1.5g of Nitrosigine vs. 8g of Citrulline Malate to achieve the same result.

WHAT IS NITROSIGINE?
HOW DOES NITROSIGINE WORK?
WHAT IS NITROSIGINE?

Nitrosigine® is a patented complex of Bonded Arginine Silicate that is scientifically engineered to deliver benefits essential to peak sports performance. Nitrosigine is a powerful and safe non-stimulant ingredient that has been clinically studied for safety and efficacy in 30 studies. The use of Nitrosigine has been shown to promote nitric oxide (NO) production for improved blood flow1, focus, and energy2

HOW DOES NITROSIGINE WORK?

The unique complex of arginine and silicon in Nitrosigine unlocks powerful synergistic effects that offer enhanced benefits. Arginine contributes to boosting nitric oxide (NO) levels, which has been shown to be a key factor in generating greater blood flow and vasodilation in working muscles. Meanwhile, silicon contributes to blood flow by strengthening and improving the flexibility of arterial walls. Together, these ingredients offer powerful efficacious results compared to each ingredient alone. Nitrosigine increases blood levels of arginine for up to six hours and elevates blood levels of silicon with a single dose.

 

Size Does Matter: In March of 2020, researchers at The University of Arkansas published an independent study that showed that a single dose of Nitrosigine increases blood flow and vasodilation. In fact, it only took 1.5g of Nitrosigine vs. 8g of Citrulline Malate to achieve the same result.

Nitrosigine, By The Numbers

20

20 patents and pending applications worldwide

35

35 supporting research studies

140

Over 140 consumer brands

Real World Results

Nutrition21 has conducted 100 studies and counting to support the safety and effectiveness of our ingredients. This research has helped us carve out unique product claims for our customers in the dietary supplement, food and beverage, and sports nutrition industries.

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  • Nitrosigine boosts key factors for increasing blood flow1
  • Nitrosigine significantly boosts nitric oxide (NO) levels1

  • Nitrosigine provides improved cognitive flexibility within just 15 minutes
  • After a single dose, Nitrosigine increases blood arginine levels in as quickly as 30 minutes and lasts up to 6 hours

  • Nitrosigine begins to increase energy levels in a single dose vs. baseline and continues to show increases in energy over time2

  • Nitrosigine boosts muscle pump, shows significant increases in muscle volume1

  • Nitrosigine significantly increases cognitive function, mental acuity, and focus
  • Nitrosigine prevented the decline in cognitive function caused by intense exercise in a research study

  • Nitrosigine reduces markers of muscle damage from exercise
  • Nitrosigine improves muscle recovery after exercise

Science That Powers Nitrosigine

Common Applications

Nitrosigine is GRAS, non-stimulant ingredient that is easily formulated into a variety of dietary supplement and functional food/beverage applications including ready to drink (RTD) beverages, pre-workout powders and dry mixes, bars, gels, capsules, and more! Nitrosigine has FDA new dietary ingredient (NDI) notification status.

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Where To Find Nitrosigine

Nutrition21 provides ingredient solutions to some of the most successful brands in the consumer marketplace today. If you are a consumer looking for the benefits of Nutrition21’s exclusive ingredients, check out our ingredients in action, on our customers’ labels:

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Nutrition21 cares about protecting consumers and brand owners alike. Let us know if you would like to hear more about how Nutrition21 is leading the industry in protecting the supply chain.

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©2023 Nutrition21, LLC. All rights reserved.       

Nitrosigine®, Velositol®, nooLVL®, Lustriva®, Chromax®, Zinmax®, and their associated logos are registered trademarks of Nutrition21, LLC.  All third party trademarks are the property of their respective owners. Nutrition21, LLC's products are protected by a number of patents including, but not limited to: US Patent Nos. 6,809,115; 6,803,456; 7,576,132; 8,062,677; 8,933,022; 9,028,879; 9,119,835; 9,597,404; 9,675,702; 10,183,049; and 10,245,325.

*These statements have not been evaluated by the Food and Drug Administration. These products are not intended to diagnose, treat, cure, or prevent any disease.

1 Results compared to baseline2 Perceived energy measured by the validated Profile of Mood States (POMS) questionnaire3 With globally sourced ingredients