Nitrosigine® is a patented complex of Bonded Arginine Silicate clinically studied and proven to boost nitric oxide production for improved blood flow, supporting oxygen and nutrient delivery, healthy working muscles, and better cognitive performance.

A powerful, safe, and non-stimulant ingredient, Nitrosigine is supported by more than 8 clinical studies and demonstrated to enhance nitric oxide levels in the body. Nitrosigine can be formulated into a range of active wellness and pre-workout products including tablets, capsules, powders, beverages, and bars.

The unique complex of arginine and silicon in Nitrosigine unlocks powerful synergistic effects that offer enhanced benefits. Arginine contributes to boosting nitric oxide (NO) levels, which has been shown to be a key factor in generating greater blood flow and vasodilation in working muscles. Meanwhile, silicon contributes to blood flow by strengthening and improving the flexibility of arterial walls. Together, these ingredients offer powerful efficacious results compared to each ingredient alone. Nitrosigine increases blood levels of arginine for up to six hours and elevates blood levels of silicon with a single dose.

Size Does Matter: In March of 2020, researchers at The University of Arkansas published an independent study that showed that a single dose of Nitrosigine increases blood flow and vasodilation. In fact, it only took 1.5g of Nitrosigine vs. 8g of Citrulline Malate to achieve the same result.

WHAT IS NITROSIGINE?
HOW DOES NITROSIGINE WORK?
WHAT IS NITROSIGINE?

Nitrosigine® is the superior nitric oxide booster, and the secret to healthy aging and whole body optimization. A patented complex of Bonded Arginine Silicate, Nitrosigine delivers a unique bioavailable form of arginine, the most important nutrient the body uses to make nitric oxide. By promoting nitric oxide production, Nitrosigine supports healthy aging across key areas of well-being including physical performance, sexual vitality, cognition, and cardiovascular health.

 

Nitrosigine’s clinically-backed efficacy and rapid action are supported by over 30 studies, including 8 clinical trials, and can be formulated into a range of healthy lifestyle products including tablets, capsules, powders, beverages, and bars.

HOW DOES NITROSIGINE WORK?

Nitrosigine boosts nitric oxide within the body, delivering the power of this miracle molecule in support of overall wellness. Nitric oxide is key to vitality, responsible for promoting optimal blood flow, as well as for supporting vascular health, neuronal function, and even sexual health.

 

Nitrosigine is rapidly absorbed within 30 minutes of consumption and quickly goes to work, boosting nitric oxide production within just 2 hours. With just a 1.5g dose, Nitrosigine increases blood flow by boosting nitric oxide levels at ⅕ the dose of citrulline, making it more potent gram for gram.

Nitrosigine white paper Nutrition21

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Nitric oxide (NO) can benefit overall well-being and healthy aging, but the ability to produce it decreases with age. See how supplements that boost NO production can stand out, in our new white paper, “The ‘Magic’ Inside: The Power of Nitric Oxide.

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Nitrosigine white paper Nutrition21

Download Our Latest White Paper

Nitric oxide (NO) can benefit overall well-being and healthy aging, but the ability to produce it decreases with age. See how supplements that boost NO production can stand out, in our new white paper, “The ‘Magic’ Inside: The Power of Nitric Oxide.

Get the Whitepaper

Nitrosigine, By The Numbers

20

20 patents and pending applications worldwide

30+

Supported by more than 30 studies, including 8 human clinical studies

2

Boosts nitric oxide production within 2 hours

Real World Results

Nutrition21 has conducted 100 studies and counting to support the safety and effectiveness of our ingredients. This research has helped us carve out unique product claims for our customers in the dietary supplement, food and beverage, and sports nutrition industries.

DOWNLOAD INFOGRAPHIC
DOWNLOAD BROCHURE

  • Nitrosigine delivers a unique and bioavailable form of arginine in the body
  • Rapidly boosts production of nitric oxide within 2 hours
  • Nitric oxide is a miracle molecule critical to maintaining the vitality of physiological systems

  • Nitrosigine promotes better blood flow helping to feed and fuel working muscles
  • Supports the delivery of the nutrients and oxygen muscles need to perform at their peak

  • By promoting nitric oxide, Nitrosigine helps keep arteries flexible, helping maintain healthy blood pressure and support cardiovascular function
  • Healthy blood flow can help support men’s sexual function

  • Nitrosigine is shown to enhancing mental flexibility and cognitive function as well as improve feelings of energy  
  • Maintaining nitric oxide levels supports healthy blood flow to and within the brain

The Superior Nitric Oxide Boosting Ingredient

Nitric oxide (NO) is a key molecule supporting overall well-being and healthy aging. Discover how Nitric Oxide boosting ingredients, like Nitrosigine®, can support an active lifestyle, cardiovascular health, cognitive health, and more!

Science That Powers Nitrosigine

Common Applications

Nitrosigine is GRAS, non-stimulant ingredient that is easily formulated into a variety of dietary supplement and functional food/beverage applications including ready to drink (RTD) beverages, pre-workout powders and dry mixes, bars, gels, capsules, and more! Nitrosigine has FDA new dietary ingredient (NDI) notification status.

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Where To Find Nitrosigine

Nutrition21 provides ingredient solutions to some of the most successful brands in the consumer marketplace today. If you are a consumer looking for the benefits of Nutrition21’s exclusive ingredients, check out our ingredients in action, on our customers’ labels:

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Nitrosigine®, Velositol®, nooLVL®, Lustriva®, Chromax®, Zinmax®, and their associated logos are registered trademarks of Nutrition21, LLC.  All third party trademarks are the property of their respective owners. Nutrition21, LLC's products are protected by a number of patents including, but not limited to: US Patent Nos. 6,809,115; 6,803,456; 7,576,132; 8,062,677; 8,933,022; 9,028,879; 9,119,835; 9,597,404; 9,675,702; 10,183,049; and 10,245,325.

*These statements have not been evaluated by the Food and Drug Administration. These products are not intended to diagnose, treat, cure, or prevent any disease.

1 Results compared to baseline2 Perceived energy measured by the validated Profile of Mood States (POMS) questionnaire3 With globally sourced ingredients