Exploring the Link Between Nitrosigine® and The Effects of Nitric Oxide

In today’s sports nutrition market, there are many workout supplements that claim they can make us stronger, leaner, and faster.  But as a consumer, how do we know which ones will actually work?  It comes down to what the science says, and science does not have an opinion, only facts.

One of the key molecules our body needs for an explosive workout is nitric oxide (NO.)  NO is one of the most important molecules for blood vessel health especially during times of exercise. It can help lower blood pressure and increase blood flow thereby providing more nutrients and oxygen to the working muscles. With increased nitric oxide levels, you’ll have a smoother ramp-up period, more powerful workout sessions, and quicker recovery.

The physiology behind how nitric oxide enhances a workout is what drove the scientists at Nutrition21 to formulate Nitrosigine®.  Nitrosigine is a non-stimulant patented complex of Bonded Arginine Silicate that has been clinically shown to deliver benefits essential to peak sports performance. Its non-stimulant characteristics enhances nitric oxide production without the jitters or crash and allows for better performance regardless of a person’s athletic status.

Since its inception, Nitrosigine has been making waves in the fitness community.  With 30 supporting research studies on safety and efficacy, over 110 consumer brands have incorporated Nitrosigine into their formulas, including superstar supplements like Alani Nu PumpBeyond® Raw LIT AF, and Ghost Brands.

Let’s explore what makes Nitrosigine so effective and how the role of nitric oxides can take your workout to new heights.


Unlock “The Power From Withinwith Nitrosigine

Nitrosigine is known to increase blood Arginine levels as quickly as 30 minutes and lasts up to six hours.  Nitrosigine’s unique complex of Arginine and Silicon unlocks powerful synergistic effects that offer enhanced benefits.  Arginine is well known to promote nitric oxide production leading to improved blood flow, focus, and energy1.  Silicon contributes to blood flow by strengthening and improving the flexibility of arterial walls.  Together, these outcomes help to enhance athletic performance, muscle pump2, and post-workout recovery.

For a closer look at Nitrosigine’s impact on the effects of nitric oxide, here are a few key highlights:


1.) Start Strong – Energy levels 

With any workout, the goal is to maximize our energy for the best results possible. While there are natural ways to boost energy levels, such as getting eight hours of sleep each night or maintaining a nutritious diet, Nitrosigine begins to increase energy1 levels in a single dose and continues to show increases in energy1 over time. 


Plus, Nitrosigine is a non-stimulant and a safe ingredient meaning you can harness energy throughout your workout without experiencing jitters or a crash.

2.) Activate & Recover Those Muscles – Effects on Blood Flow

An independent study published March 2020 from The University of Arkansas showed that it only takes 1.5g of Nitrosigine vs. 8g of Citrulline Malate (another supplement associated with improved blood flow) to achieve equivalent and significant increases in blood flow and vasodilation.

Due to the increase in blood flow, more nutrients and oxygen can be distributed to active muscles. The final outcome: Nitrosigine boosts muscle pump and shows significant increases in muscle volume2.

Additionally, Nitrosigine has been shown to reduce markers of muscle damage from exercise and improve post-workout muscle recovery.  This means that Nitrosigine is effective both during and after an intense workout, allowing you to get back at it again tomorrow.


3.) Get In The Zone – Cognitive function, mental acuity, and focus

It’s not uncommon for people to lose focus during a workout.  Luckily, there are plenty of natural ways to combat these distractions and stay on track with your fitness goals, including listening to music you enjoy, drinking plenty of water before, during, and after the workout, or switching up your daily routine.

Adding Nitrosigine to any workout regimen has also been shown to significantly increase cognitive function, mental acuity, and focus. How does Nitrosigine do this? The increased blood flow caused by elevated nitric oxide production reaches numerous areas of the body including the brain, where it delivers more oxygen and nutrients.


Overall, the impact of Nitrosigine on effects mediated by nitric oxide production has been shown to enhance the performance of athletes or those undergoing rigorous exercise. To take your workout to the next level, check out this list of top-notch supplements featuring Nitrosigine! 


1Perceived energy measured by the validated Profile of Mood States (POMS) questionnaire 

2Results compared to baseline